Publications
2022
97. Nguyen LTS, Jacob MAC, Parajón E, and Robinson DN*. Cancer as a biophysical disease: targeting the mechanical-adaptability program. Biophys.J. 2022; DOI:https://doi.org/10.1016/j.bpj.2022.04.039 / PDF
96. Angstadt S, Zhu Q, Jaffee EM, Robinson DN*, and Anders RA*. Pancreatic ductal adenocarcinoma cortical mechanics and clinical implications. Frontiers in Oncology, 2022; 12: 1-15. https://doi.org/10.3389/fonc.2022.809179 / PDF
2021
95. DiNapoli, KT, Robinson DN, Iglesias PA. A mesoscale mechanical model of cellular interactions. Biophys. J. 120: 4905-4917. doi: https://doi.org/10.1016/j.bpj.2021.10.021 / PDF
94. Srivastava V, Balaban AE. Robinson DN*. Cytokinesis. In Joseph Jez (ed) The Encyclopedia of Biological Chemistry 3rd Edition, 2021; Oxford: Elsevier. Vol. 5, pp. 42-48. doi:10.1016/B978-0-12-819460-7.00067-0. / PDF
93. Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial metabolism, surface hydration, and ciliary function. J. Cell Sci. 2021; 134(4): jcs257162. / PDF Featured in Scientific American
92. Nguyen JMK, Robinson DN*, Sidhaye VK*. Why New Biology Must Be Uncovered to Advance Therapeutic Strategies for Chronic Obstructive Pulmonary Disease. Am. J. Phys. Lung Cell Mol. Physiol. 2021; 320: L1–L11. DOI: 10.1152/ajplung.00367.2020 / PDF
91. Parajón E, Surcel A, Robinson DN*. The Mechanobiome: A Goldmine for Cancer Therapeutics. Am. J. Physiol.-Cell Physiol. 2021; 320: C306-C323. DOI: 10.1152/ajpcell.00409.2020 / PDF
2020
90. DiNapoli K, Robinson DN, Iglesias PA. Tools for computational analysis of moving boundary problems in cellular mechanobiology. WIREs Mech. Dis. 2020; e1514 1-33. doi.org/10.1002/wsbm.1514 / PDF
89. Bryan DS, Stack M, Krystofiak K, Cichoń U, Thomas DG, Surcel A, Schiffhauer ES, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR. 4-hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis. Proc. Natl. Acad. Sci. USA. 2020; . doi.org/10.1073/pnas.2014639117 / PDF
88. Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial homeostasis, mitochondrial metabolism and ciliary function. bioRxiv DOI: 10.1101/2020.05.18.101378. / PDF
87. Nguyen L, Robinson DN*. The Unusual Suspects in Cytokinesis: Fitting the Pieces Together. Front. Cell Dev. Bio. 2020; 8:441. DOI: 10.3389/fcell.2020.00441. / PDF
86. Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell K, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau A, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE. TRPV4 disrupts mitochondrial transport and causes axonal degeneration via CaMKII-dependent elevation of intracellular Ca2+. Nat. Comm. 2020; 11(1):2679. doi: 10.1038/s41467-020-16411-5. / PDF
85. Crews DC, Wilson KL, Sohn J, Kabacoff CM, Poynton SL, Murphy LR, Bolz J, Wolfe A, White PT, Will C, Collins C, Gauda E, Robinson DN*. Helping scholars overcome socioeconomic barriers to medical and biomedical careers: Creating a pipeline initiative. Teach. Learn. Med. 2020; 32(4): 422-433. doi.org/10.1080/10401334.2020.1729161 / PDF
2019
84. Kothari P, Johnson C, Sandone C, Iglesias PA, Robinson DN*. How the mechanobiome drives cell behavior, viewed through the lens of control theory. J. Cell Sci. 2019; 132:1-10. jcs234476. / PDF
83. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14. Cancer Res. 2019; 79(18):4665-4678. / PDF
82. Surcel A, Robinson DN.* Meddling with myosin’s mechanobiology in cancer. Proc. Natl. Acad. Sci. U.S.A. 2019; 116(31): 15322-15323. / PDF
81. Schiffhauer ES, Ren Y, Iglesias V, Kothari P, Iglesias PA, Robinson DN*. Myosin IIB assembly-state determines myosin IIB mechanosensitive dynamics. J. Cell Biol. 2019; 218(3): 895-908. / PDF
80. Kothari P, Srivastava V, Aggarwal V, Tchernyshyov I, Van Eyk J, Ha T, and Robinson DN*. Contractility kits promote assembly of the mechanoresponsive cytoskeletal network. J. Cell Sci. 2019; 132(2): 1-12. / PDF
2018
79. Liu Y and Robinson D*. Recent advances in cytokinesis: Understanding the molecular underpinnings. F1000Research 2018; 7(F1000 Faculty Rev): 1849. / PDF
78. Duan R, Kim JH, Shilagardi K, Schiffhauer E, Lee, D, Son S, Li S, Thomas C, Luo T, Fletcher DA, Robinson DN, Chen EH. Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion. Nat. Cell Biol. 2018; 20, 688–698. [Available as a preprint on bioRxiv; DOI: 10.1101/154831] / PDF
77. West-Foyle H, Kothari P, Osborne J, Robinson DN*. 14-3-3 proteins tune non-muscle myosin-II assembly. J. Biol. Chem. 2018; 293(18), 6751-6761. / PDF
76. Evans JP, Robinson DN. Micropipette aspiration of oocytes to assess cortical tension. Mouse oocyte development – Methods and Protocols, Eds M.H. Verlhac, and M.E. Terret. Methods Mol. Biol. 2018; 1818: 163-171. / PDF
2017
75. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion. bioRxiv; DOI: 10.1101/190553. / PDF
74. Miao C, Schiffhauer ES, Okeke EI, Robinson DN, Luo T. Parallel compression is a fast, low-cost assay for the high throughput screening of mechanosensory cytoskeletal proteins in cells. ACS Appl. Mater. Interfaces 2017; 9(34): 28168–28179. / PDF
73. Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. Entosis is induced by glucose starvation. Cell Rep. 2017; 20: 201-210. / PDF
72. Nishida K, Brune KA, Putcha N, Mandke P, O’Neal WK, Shade D, Srivastava V, Wang M, An SS, Drummond MB, Hansel NN, Robinson DN, Sidhaye V. Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension. Am. J. Physiol. – Lung Cell Mol. Physiol. 2017; 313(3): L581-L591. / PDF
71. Thomas DG, Robinson DN*. The fifth sense: Mechanosensory regulation of alpha-actinin-4 and its relevance for cancer metastasis. Sem. Cell Dev. Biol. 2017; 71: 68-74. / PDF
70. Schiffhauer ES, Robinson DN.* Mechanochemical signaling directs cell shape change. Biophys. J. 2017; 112: 207-214. / PDF
69. Kothari P, Schiffhauer ES, Robinson DN.* Cytokinesis from nanometers to micrometers and microseconds to minutes. Methods Cell Biol. 2017;137:307-322. / PDF
2016
68. Ibo M, Srivastava V, Robinson DN, Gagnon Z. Cell Blebbing in Confined Microfluidic Environments. PLoS One 2016; 11(10): e0163866. / PDF
67. Ngo T, Miao X, Robinson DN, Zhou Q-q. An RNA-binding protein, RNP-1, protects microtubules from nocodazole and localizes to the leading edge during cytokinesis and cell migration in Dictyostelium cells. Acta Pharmacologica Sinica 2016; 37: 1449-1457. / PDF
66. Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, Liu Y, Wu N, Joseph NE, Wang T-L, Zhang N, Pan D, Alpini G, Robinson DN, Anders RA. Yes-Associated Protein impacts adherens junction assembly through regulating actin cytoskeleton organization. Am. J. Physiol. – Gastrointest. Liver Phys. 2016; 311(3): G396-G411. / PDF
65. Schiffhauer ES, Luo T, Mohan K, Srivastava V, Qian X, Griffis E, Iglesias PA, Robinson DN*. Mechanoaccumulative elements of the mammalian actin cytoskeleton. Curr. Biol. 2016; 26(11): 1473-1479. / PDF
64. Mackenzie ACL, Kyle DD, McGinnis LA, Lee HJ, Aidana N, Robinson DN, Evans JP. Cortical mechanics and myosin-II abnormalities associated with post-ovulatory aging: Implications for functional defects in aged eggs. Mol. Hum. Reprod. 2016; 22(6): 397-409. / PDF
63. Christianson MS, Gerolstein AL, Lee HJ, Monseur BC, Robinson DN, Evans JP. Effects of inhibition of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) on sperm incorporation and cortical tension in mouse eggs. Mol. Reprod. Dev. 2016; 183(3): 188-189. / PDF
62. Srivastava V, Iglesias PA, Robinson DN*. Cytokinesis: Robust cell shape regulation. Semin. Cell Dev. Biol. 2016; 53:39-44. / PDF
2015
61. Mohan K, Luo T, Robinson DN, Iglesias PA. Cell shape regulation through mechanosensory feedback control. J. R. Soc. Interface. 2015; 12(109): 20150512. / PDF
60. McGinnis L, Lee H, Robinson DN, Evans JP. MAPK3/1 (ERK1/2) and myosin light chain kinase in mammalian eggs affect myosin-II function and regulate the metaphase II state in a calcium- and zinc- dependent manner. Biol. Reprod. 2015; 92(6): 146 (1-14). / PDF
59. Kim JH, Ren Y, Ng WP, Li S, Son S, Kee Y-S, Zhang S, Zhang G, Fletcher DA, Robinson DN, Chen EH. Mechanical tension drives cell membrane fusion. Dev. Cell 2015; 32(5): 561-573. / PDF
58. Srivastava V, Robinson DN*. Mechanical stress and network structure drive protein dynamics during cytokinesis. Curr. Biol. 2015; 25(5): 663-670. / PDF
57. Surcel A, Ng WP, West-Foyle H, Zhu Q, Ren Y, Avery L, Krenc AK, Meyers D, Rock RS, Anders RA, Freel Meyers C, Robinson DN*. Pharmacological activation of myosin II paralogs to correct cell mechanics defects. Proc. Natl. Acad. Sci. USA 2015; 112(5): 1428-1433. / PDF
56. Luo T*, Robinson DN*. Kinetic Monte Carlo simulations of the assembly of filamentous biomacromolecules by the dimer addition mechanism. RSC Adv. 2015; 5(6): 3922-3929. / PDF
2014
55. Ren Y, West-Foyle H, Surcel A, Miller C, Robinson DN*. Genetic suppression of a phosphomimic myosin II identifies system-level factors promoting myosin II cleavage furrow accumulation. Mol. Biol. Cell. 2014; 25(25): 4150-4165. / PDF
54. Sun Q, Luo T, Ren Y, Florey O, Shirasawa S, Sasazuki T, Robinson DN, Overholtzer M. Competition between human cells by entosis. Cell Res. 2014; 24: 1299-1310. / PDF
53. Luo T, Srivastava V, Ren Y, Robinson DN.* Mimicking the mechanical properties of the cell cortex by the self-assembly of an actin cortex in vesicles. App. Phys. Lett. 2014; 104: 153701-1-5. / PDF
2013
52. Luo T, Mohan K, Iglesias PA, Robinson DN*. Molecular mechanisms of cellular mechanosensing. Nat. Mater. 2013; 12: 1064-1071. / PDF
51. Kryzak CA, Moraine MM, Kyle DD, Lee HJ, Robinson DN, Evans JP. Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy. Biol. Reprod. 2013; 89: 44, 1-13. / PDF
50. Kabacoff C, Srivastava V, Robinson DN*. A Summer Academic Research Experience for Disadvantaged Youth. CBE Life Sci. Educ. 2013; 12: 410-418. / PDF
49. Kee YS, Robinson DN.* Micropipette Aspiration for Studying Cellular Mechanosensory Responses and Mechanics. Methods Mol. Biol. 2013; 983:367-382. / PDF
48. Srivastava V, Robinson DN.* Cytokinesis. In Lennarz & Lane (eds.) The Encyclopedia of Biological Chemistry 2nd Edition, 2013; Waltham, MA: Academic Press. Vol. 1, pp. 622-626. / PDF
2012
47. Robinson DN*, Iglesias PA*. Bringing the physical sciences into your cell biology research. Mol. Biol. Cell 2012; 23(21): 4167-4170. / PDF
46. Robinson DN*, Kee Y-S, Luo T, Surcel A. Understanding how dividing cells change shape. In Egelman EH (ed.) Comprehensive Biophysics, 2012; Elsevier, Amsterdam. Vol. 7, pp. 48-72. / PDF
45. Dickinson D, Robinson DN, Nelson WJ, Weis WI. α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev. Cell 2012; 23: 533-546. / PDF
44. West-Foyle H, Robinson DN.* Cytokinesis Mechanics and Mechanosensing. Cytoskeleton 2012; 69(10): 700-709. / PDF
43. Sidhaye VK, Chau E, Srivastava V, Sirimalle S, Balabhadrapatruni C, Aggarwal NR, D’Alessio FR, Robinson DN, King LS. A novel role for aquaporin-5 in enhancing microtubule organization and stability. PLoS ONE 2012; 7(6): e38717. / PDF
42. Mohan K, Iglesias PA*, Robinson DN.* Separation anxiety: stress, tension, and cytokinesis. Exp. Cell Res. 2012; 318(12): 1428-1434. / PDF
41. Poirier CC, Ng WP, Robinson DN, Iglesias PA. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comp. Biol. 2012; 8(4): e1002467. / PDF
40. Kee YS, Ren Y, Dorfman D, Iijima M, Firtel RA, Iglesias PA, Robinson DN.* A mechanosensory system governs myosin II accumulation in dividing cells. Mol. Biol. Cell 2012; 23(8): 1510-1523. / PDF
39. Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN.* Understanding the cooperative interactions between myosin II and actin crosslinkers mediated by actin filaments during mechanosensation. Biophys. J. 2012; 102(2): 238-247. / PDF
2011
38. Evans JP, Robinson DN. The spatial and mechanical challenges of female meiosis. Mol. Reprod. Dev. 2011; 78:769-777. / PDF
37. Wang Y, Steimle PA, Ren Y, Ross CA, Robinson DN, Egelhoff TT, Sesaki H, Iijima M. Dictyostelium huntingtin controls chemotaxis and cytokinesis through regulation of myosin II phosphorylation. Mol. Biol. Cell 2011; 22:2270-2281. / PDF
36. Luo T, Robinson DN.* The role of the actin cytoskeleton in mechanosensation. Kamkin A. & Kiseleva I. eds. Mechanosensitivity in Cells and Tissues 4: Mechanosensitivity and Mechanotransduction, 2011; Springer-Verlag, New York. pp. 25-65. / PDF
2010
35. Robinson DN.* 14-3-3, an integrator of cell mechanics and cytokinesis. Small GTPases 2010; 1(3):165-169. / PDF
34. Surcel A, Kee Y-S, Luo T, Robinson DN.* Cytokinesis through biochemical-mechanical feedback loops. Semin. Cell Dev. Biol. 2010; 21:866-873. / PDF
33. Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Will ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN.* 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889. / PDF
32. Larson SM, Lee HJ, Hung P-h, Matthews LM, Robinson DN*, Evans JP*. Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and ezrin-radixin-moesin (ERM) proteins. Mol. Biol. Cell 2010; 21:3182-3192. / PDF
31. Lee S, Shen Z, Robinson DN, Briggs S, Firtel RA. Involvement of the cytoskeleton in controlling leading edge function during chemotaxis. Mol. Biol. Cell 2010; 21(11):1810-1824. / PDF
30. Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA. Automated characterization of cell shape changes during amoeboid motility. BMC Systems Biology 2010; 4:33. / PDF
2009
29. Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock, RS, Robinson DN.* Mechanosensing through cooperative interactions between myosin-II and the actin crosslinker cortexillin-I. Curr. Biol. 2009; 19(17):1421-1428. / PDF
28. Tikhonenko I, Nag DK, Robinson DN, Koonce MP. A novel role for a central motor kinesin in connecting the nucleus and MTOC. Euk. Cell 2009; 8(5):723-731. / PDF
2008
27. Yang L, Effler JC, Kutscher BL, Sullivan SP, Robinson DN, Iglesias PA. Modeling cellular deformations using the level set formalism. BMC Systems Biology 2008; 2:68. / PDF
26. Reichl EM, Ren Y, Morphew MK, Delannoy M, Effler JC, Girard KD, Divi S, Iglesias PA, Kuo SC, Robinson DN.* Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics. Curr. Biol. 2008; 18(7):471-480. / PDF
25. Kee YS, Robinson DN.* Motor Proteins: Myosin mechanosensors. Curr. Biol. 2008; 18(18): r860-r862. / PDF
2007
24. Reichl EM, Robinson DN.* Putting the brakes on cytokinesis with alpha-actinin. Dev. Cell 2007; 13: 460-462. / PDF
23. Effler JC, Iglesias PA, Robinson DN.* A mechanosensory system controls cell shape during mitosis. Cell Cycle 2007; 6(1):30-35. / PDF
22. Kabacoff C, Xiong Y, Musib R, Reichl EM, Kim J, Iglesias PA, Robinson DN.* Dynacortin facilitates polarization of chemotaxing cells. BMC Biol. 2007; 5:53. / PDF
21. LeDuc PR*, Robinson DN.* Using lessons from cellular and molecular structures for future materials. Adv. Mat. 2007; 19(22):3761-3770. / PDF
2006
20. Effler JC, Iglesias PA, Robinson DN. Regulating cell shape during cytokinesis. In B.A. Francis and J.C. Willems, eds, Control of Uncertain Systems: Modelling, Approximation and Design, 2006; pp. 203-224. Springer-Verlag, New York. / PDF
19. Octtaviani E, Effler JC, Robinson DN.* Enlazin, a natural fusion of two classes of canonical cytoskeletal proteins, contributes to cytokinesis dynamics. Mol. Biol. Cell. 2006; 17(12):5275-5286. / PDF
18. Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN.* Mitosis-specific mechanosensing and contractile protein redistribution control cell shape. Curr. Biol. 2006; 16(19):1962-1967. / PDF
17. Girard KD, Kuo SC, Robinson DN.* Dictyostelium myosin-II mechanochemistry promotes active behavior of the cortex on long time-scales. Proc. Natl. Acad. Sci. USA 2006; 103(7):2103-2108. / PDF
2005
16. Zhang W., Robinson DN.* Balance of actively generated contractile and resistive forces controls cytokinesis dynamics. Proc. Natl. Acad. Sci. USA 2005; 102(20):7186-7191. / PDF
15. Reichl EM, Effler JC, Robinson DN.* Stress and strain of cytokinesis. Trends Cell Biol. 2005; 15(4):200-206. / PDF
2004
14. Robinson DN*, Spudich JA. Mechanics and regulation of cytokinesis. Curr. Opin. Cell Biol. 2004; 16(2):182-188. / PDF
13. Girard KD, Chaney C, Delannoy M, Kuo SC, Robinson DN.* Dynacortin contributes to cortical viscoelasticity and helps determine the shape changes of cytokinesis. EMBO J. 2004; 23(7):1536-1546. / PDF
2002
12. Robinson DN*, Girard KD, Octtaviani E, Reichl EM. Dictyostelium cytokinesis: From molecules to mechanics. J. Musc. Res. Cell Motil. 2002; 23(7-8):719-727. / PDF
11. Robinson DN*, Cavet G, Warrick HM, Spudich JA. Quantitation of the distribution and flux of myosin-II during cytokinesis. BMC Cell Biology 2002; 3:4. / PDF
10. Robinson DN*, Ocon SS, Rock RS, Spudich JA. Dynacortin is a novel actin bundling protein that localizes to dynamic actin structures. J. Biol. Chem. 2002; 277(11):9088-9095. / PDF
2001
9. Robinson DN.* Cell division: Biochemically controlled mechanics. Curr. Biol. 2001; 11(18):R737-740. / PDF
2000
8. Robinson DN*, Spudich JA. Dynacortin, a genetic link between equatorial contractility and global shape control discovered by library complementation of a Dictyostelium cytokinesis mutant. J. Cell Biol. 2000; 150(4):823-838. / PDF
7. Robinson DN*, Spudich JA. Towards a molecular understanding of cytokinesis. Trends Cell Biol. 2000; 10(6):228-237. / PDF
1997
6. Robinson DN, Cooley L. Genetic analysis of the actin cytoskeleton in the Drosophila ovary. Annu. Rev. Cell Dev. Biol. 1997; 13:147-170. / PDF
5. Robinson DN, Cooley L. Drosophila kelch is an oligomeric ring canal actin organizer. J. Cell Biol. 1997; 138(4):799-810. / PDF
4. Robinson DN, Cooley L. Examination of two kelch proteins produced by stop codon suppression. Development 1997; 124(7):1405-1417. / PDF
3. Robinson DN, Smith TA, Sokol NS, Hudson AM, Cooley L. Formation of the Drosophila ovarian ring canal inner rim depends on cheerio. Genetics 1997; 145(4):1063-1072. / PDF
1996
2. Robinson DN, Cooley L. Stable intercellular bridges in development: The cytoskeleton lining the tunnel. Trends Cell Biol. 1996; 6(12):474-479. / PDF