To See the World in a Dividing Cell
If you are interested in supporting our research or our Johns Hopkins Initiative for Careers in Science and Medicine and the Summer Academic Research Experience program for low-income Baltimore youth, please contact Doug (email@example.com), Sarah Farrell, Director of Development (firstname.lastname@example.org), or Katie Sullivan, Associate Director of Development (email@example.com), Institute for Basic Biomedical Sciences.
Jan 20, 2020: Doctoral Diversity Program Scholar and now 2nd-yr medical student Michelle Colbert and I got to share the story of the Johns Hopkins Initiative for Careers in Science and Medicine on "Midday with Tom Hall on WYPR (88.1) in Baltimore. Michelle was awesome in this interview! Here is the link: MLK Jr. Day of Service, Pt 2: Hopkins' Careers in Science & Medicine Initiative
Jan 3, 2020: Today, we celebrated Priyanka Kothari's completion of her doctoral research on the Mechanoresponsive Contractility Kits! Congrats, Dr. Kothari!
Dec 2, 2019: Thanks Ashanti Edwards and Ahna Skop for inviting us to prepare a piece for the ASCB newsletter in which we describe the Johns Hopkins Initiative for Careers in Science and Medicine.
Nov 29, 2019: Check out the interviews with three Summer Academic Research Experience (SARE) alums: Q&A — The Next Generation of Scientific Researchers.
Nov 22, 2019: November is COPD Awareness Month. Chronic Obstructive Pulmonary Disease is currently the 3rd leading cause of disease-associated death in the U.S., and yet no therapeutic strategy directly addresses the root cause of the disease. To address complex diseases like COPD requires an interdisciplinary team, and thankfully we have had the opportunity to build such a team that includes two pulmonary physician scientists Ramana Sidhaye and Corrine Kliment and a pharmacology doctoral student Jenny Nguyen. Thank you, Biophysical Society, for sharing our work on your blog.
Oct 17, 2019: Check out the new Technology Feature by Vivien Marx in Nature Methods. Vivien highlights some of the breakthroughs and impact in the mechanobiology field. Thanks, Vivien, for writing this!
Sept 18, 2019: Check out the press release on our new Cancer Research paper: Johns Hopkins Researchers ID Compound That Could Play A Novel Role In Halting Pancreatic Cancer Progression
May 24, 2019: Our lab's mission - the galaxy depends on us! :-)
Apr 9, 2019: Congratulations to Priyanka for winning the David Yue Award as part of the School of Medicine's Young Investigator's Day recognition! Read Priyanka's YIDP interview here.
May 15, 2018: Doug was awarded the Provost's Prize for Faculty Excellence in Diversity.
Jun 2, 2017: You can listen to Doug's ASBMB Ruth Kirschstein Diversity of Science Award talk here.
Jun 2, 2017: See Doug's ASBMB interview for his recognition by ASBMB's Ruth Kirschstein Diversity of Science Award.
Feb 24, 2017: Check out the Baltimore Sun article on our new DARPA-funded project. We are aiming to engineer Dictyostelium cells to be able to perform specific tasks.
Feb 19, 2017: Check out our video describing our outreach program, the Johns Hopkins Initiative for Careers in Science and Medicine.
Feb 2, 2017: Doug is selected as a Science Super Hero by Discovery Communications. The goal of the program is to call attention to the impact of science on community. We thank Discovery Communications for their recognition of our efforts.
Dec 12, 2016: Check out our Op-Ed piece in support of the federal Health Careers Opportunity Program: Don’t cut a federal program that helps disadvantaged students enter health careers. Please remind your senators and representatives how much impact we can have for a pretty small investment!
Mar 4, 2016: Corrine Kliment was just awarded the Baurenschmidt Award from the Eudowood Board. Congrats, Corrine! You can read more about Corrine's work in this ASCB write up.
Dec 14, 2015: Please check out our ASCB Celldance Video. We attempted to present how you go from basic science discovery to making an impact on a disease, in this case on pancreatic cancer. The Celldance Videos are designed to communicate our science stories through live cell imaging for a general audience. The press release may be found here.
Aug 22, 2015: Check out this video on our 4-HAP work on ScIQ, TYT's New Science Channel: Enjoy!
Jun 10, 2015: Check out Mariya Khan's animatic depicting the design constraints of a dividing cell. Please make sure your sound is turned on.
See our newest press releases:
Wanted: Self-Driving Cells to Pursue Deadly Bacteria: Johns Hopkins Team Aims to Make Micro-Soldiers That Seek Out and Subdue Pathogens
Drawing on their expertise in control systems and cell biology, Johns Hopkins University researchers are setting out to design and test troops of self-directed microscopic warriors that can locate and neutralize dangerous strains of bacteria. Please see the full story here.
Cellular 'Cruise Control' Systems Let Cells Sense and Adapt to Changing Demands
Cells are the ultimate smart material. They can sense the demands being placed on them during critical life processes and then respond by strengthening, remodeling or self-repairing, for instance. To do this, cells use “mechanosensory” systems similar to the cruise control that lets a car’s engine adjust its power output when going up or down hills. Researchers are uncovering new details on cells’ molecular cruise control systems. By learning more about the inner workings of these systems, scientists hope ultimately to devise ways to tinker with them for therapeutic purposes. Please check out the rest of the story on National Insitute of General Medical Science's BioBeat.
Proteins Pull Together As Cells Divide: Group dynamics, not star proteins, drive mechanics of crucial cell process
Like a surgeon separating conjoined twins, cells have to be careful to get everything just right when they divide in two. Otherwise, the resulting daughter cells could be hobbled, particularly if they end up with too many or two few chromosomes. Successful cell division hangs on the formation of a dip called a cleavage furrow, a process that has remained mysterious. Now, researchers at Johns Hopkins have found that no single molecular architect directs the cleavage furrow’s formation; rather, it is a robust structure made of a suite of team players. This work appeared online in Current Biology on February 19, 2015. Please click here for the rest of the story.
Under Pressure: Mechanical stress is a key driver of cell-cell fusion, study finds
Just as human relationships are a two-way street, fusion between cells requires two active partners: one to send protrusions into its neighbor, and one to hold its ground and help complete the process. Researchers have now found that one way the receiving cell plays its role is by having a key structural protein come running in response to pressure on the cell membrane, rather than waiting for chemical signals to tell it that it’s needed. The study, which helps open the curtain on a process relevant to muscle formation and regeneration, fertilization, and immune response, appears in the March 9 (2015) issue of the journal Developmental Cell. Please click here for the rest of the story.
Stiffening Up Cancer Cells
A new screen uncovers compounds that alter cell mechanics. Could these compounds someday treat cancer from an unexpected angle? Find out by reading the story in Biotechniques.
New Cancer-Fighting Strategy Would Harden Cells to Prevent Metastasis
Existing cancer therapies are geared toward massacring tumor cells, but Johns Hopkins researchers propose a different strategy: subtly hardening cancer cells to prevent them from invading new areas of the body. They devised a way of screening compounds for the desired effect and have identified a compound that shows promise in fighting pancreatic cancer. Their study appeared January 20, 2015 in the early edition of the Proceedings of the National Academy of Sciences. Please click here for the rest of the story.
My Lab's Training Outcomes:
A new coalition of 9 top universities and an institute calls for transparency in the outcomes and demographics of every institution's training programs (here is the Science Magazine writeup). We do not need a mandate to provide that information. Here are my lab's trainee outcomes and demographics:
To date, 76 members have passed through our lab, including 15 doctoral students (5 current), 6 postdoctoral fellows (1 current), 1 clinical fellow, 22 undergraduate and medical students, 7 technicians, 3 Art as Applied to Medicine masters students, and 24 outreach and high school students. Two students spent summers as undergrads in the lab then returned for their doctoral training. The 76 includes 49 (64%) women and 20 (26%) Underrepresented in Science (UIS) or Medicine (UIM). We have also had 5 visiting scientists spend extended periods of time in the lab.
My doctoral students complete their degrees in an average of 5.6 years (median 5.3 years) and produce an average of 6.3 papers (range 4-10; mean of 2.8 first author). My postdoctoral fellows have completed in an average of 4.2 years (median 2.5 years) and produced an average of 4.8 papers (range 1-13; mean of 2.2 first author).
Example career outcomes of my doctoral and postdoctoral trainees include tenure track faculty (60% of postdocs, approximately 4-times the national rate), science writing, patent law, FDA reviewing, and scientists in biotech (e.g. Abbvie, Genentech, and SocialCode).
My undergraduates have gone on to medical school (in one case with a $120,000 scholarship to U. Pittsburgh based on his work in my lab), graduate school (e.g. Northwestern, UC Berkeley, UNC Chapel Hill), and MSTP programs (e.g. Cornell-Rockefeller). In two cases, my summer undergraduate students (one through the Summer Internship Program (SIP) and one (a UIS) from the Research Experience for Undergraduates (REU)) returned to my lab for their doctoral studies.
My high school students have all moved on to college, including students from low-income backgrounds (many of whom are pursuing STEM or health-related degrees) that have come through my lab’s Summer Academic Research Experience (SARE) program (Kabacoff et al. CBE Life Sci. Educ. 2013; http://sare.cellbio.jhmi.edu). Please note that SARE itself has now served 95 high school scholars, over 92% of those who have reached college age are confirmed to have matriculated into 4-year college programs, and 59% have chosen STEM majors. SARE also has nearly a 70% college completion rate by five years post high school graduation, which compares favorably to the 14% national average for students from low-income backgrounds.