
Pablo Iglesias
pi@jhu.edu
Academic Titles
Professor of Electrical Engineering
Publications
- 110. Kuhn JA, Banerjee P, Haye A, Robinson DN, Iglesias PA, Devreotes PN. Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity. Nat. Comm. 2025; In press.
- 109. Lin Y, Parajón E, Yuan Q, Ye S, Qin G, Deng Y, Borleis J, Koyfman A, Iglesias PA, Konstantopoulos K, Robinson DN, Devreotes PN. Dynamic and biphasic regulation of cell migration by Ras. bioRxiv; 2025, Feb. 16. DOI: https://doi.org/10.1101/2025.02.13.638204
- 108. Dolgitzer D, Plaza-Rodriguez AI, Iglesias MA, Jacob MAC, Todd BA, Robinson DN, Iglesias PA. A continuum model of mechanosensation based on contractility kit assembly. Biophys. J. 2025; 124: 1-15. DOI: doi.org/10.1016/j.bpj.2024.10.020 / PDF
- 107. Razavi S, Wong F, Abubaker-Sharif B, Matsubayashi H, Nakamura H, Nguyen NTH, Robinson DN, Chen B, Iglesias PA, Inoue T. Synthetic control of actin polymerization and symmetry breaking in active protocells. Sci. Adv. 2024; 10(24): 1-11. DOI: 10.1126/sciadv.adk9731 / PDF
- 105. Kuhn JA, Banerjee P, Haye A, Robinson DN, Iglesias PA, Devreotes PN. Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity. bioRxiv; 2024. Feb. 13. DOI: https://doi.org/1101/2024.02.13.580131.
- 103. Razavi S, Wong F, Abubaker-Sharif B, Matsubayashi HT, Nakamura H, Sandoval E, Robinson DN, Chen B, Liu J, Iglesias PA, Inoue T. Synthetic control of actin polymerization and symmetry breaking in active protocells. bioRxiv, 2023. Sep. 23; doi: 10.1101/2023.09.22.559060
100. Plaza-Rodriguez A., Nguyen LTS, Robinson DN, Iglesias, PA. Particle-based model of mechanosensory contractility kit assembly. Biophys. J. 2022; 121: 1-15. DOI:https://doi.org/10.1016/j.bpj.2022.10.031 / PDF
- 95. DiNapoli, KT, Robinson DN, Iglesias PA. A mesoscale mechanical model of cellular interactions. Biophys. J. 120: 4905-4917. doi: https://doi.org/10.1016/j.bpj.2021.10.021 / PDF
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93. Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial metabolism, surface hydration, and ciliary function. J. Cell Sci. 2021; 134(4): jcs257162. / PDF Featured in Scientific American
- 90. DiNapoli K, Robinson DN, Iglesias PA. Tools for computational analysis of moving boundary problems in cellular mechanobiology. WIREs Mech. Dis. 2020; e1514 1-33. doi.org/10.1002/wsbm.1514 / PDF
- 88. Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial homeostasis, mitochondrial metabolism and ciliary function. bioRxiv DOI: 10.1101/2020.05.18.101378. / PDF
84. Kothari P, Johnson C, Sandone C, Iglesias PA, Robinson DN*. How the mechanobiome drives cell behavior, viewed through the lens of control theory. J. Cell Sci. 2019; 132:1-10. jcs234476. / PDF
- 83. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14. Cancer Res. 2019; 79(18):4665-4678. / PDF
- 81. Schiffhauer ES, Ren Y, Iglesias V, Kothari P, Iglesias PA, Robinson DN*. Myosin IIB assembly-state determines myosin IIB mechanosensitive dynamics. J. Cell Biol. 2019; 218(3): 895-908. / PDF
- 75. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion. bioRxiv; DOI: 10.1101/190553. / PDF
- 65. Schiffhauer ES, Luo T, Mohan K, Srivastava V, Qian X, Griffis E, Iglesias PA, Robinson DN*. Mechanoaccumulative elements of the mammalian actin cytoskeleton. Curr. Biol. 2016; 26(11): 1473-1479. / PDF
- 62. Srivastava V, Iglesias PA, Robinson DN*. Cytokinesis: Robust cell shape regulation. Semin. Cell Dev. Biol. 2016; 53:39-44. / PDF
- 61. Mohan K, Luo T, Robinson DN, Iglesias PA. Cell shape regulation through mechanosensory feedback control. J. R. Soc. Interface. 2015; 12(109): 20150512. / PDF
52. Luo T, Mohan K, Iglesias PA, Robinson DN*. Molecular mechanisms of cellular mechanosensing. Nat. Mater. 2013; 12: 1064-1071. / PDF
- 47. Robinson DN*, Iglesias PA*. Bringing the physical sciences into your cell biology research. Mol. Biol. Cell 2012; 23(21): 4167-4170. / PDF
- 42. Mohan K, Iglesias PA*, Robinson DN.* Separation anxiety: stress, tension, and cytokinesis. Exp. Cell Res. 2012; 318(12): 1428-1434. / PDF
- 41. Poirier CC, Ng WP, Robinson DN, Iglesias PA. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comp. Biol. 2012; 8(4): e1002467. / PDF
- 40. Kee YS, Ren Y, Dorfman D, Iijima M, Firtel RA, Iglesias PA, Robinson DN.* A mechanosensory system governs myosin II accumulation in dividing cells. Mol. Biol. Cell 2012; 23(8): 1510-1523. / PDF
- 39. Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN.* Understanding the cooperative interactions between myosin II and actin crosslinkers mediated by actin filaments during mechanosensation. Biophys. J. 2012; 102(2): 238-247. / PDF
- 33. Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Will ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN.* 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889. / PDF
- 30. Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA. Automated characterization of cell shape changes during amoeboid motility. BMC Systems Biology 2010; 4:33. / PDF
- 29. Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock, RS, Robinson DN.* Mechanosensing through cooperative interactions between myosin-II and the actin crosslinker cortexillin-I. Curr. Biol. 2009; 19(17):1421-1428. / PDF
- 27. Yang L, Effler JC, Kutscher BL, Sullivan SP, Robinson DN, Iglesias PA. Modeling cellular deformations using the level set formalism. BMC Systems Biology 2008; 2:68. / PDF
26. Reichl EM, Ren Y, Morphew MK, Delannoy M, Effler JC, Girard KD, Divi S, Iglesias PA, Kuo SC, Robinson DN.* Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics. Curr. Biol. 2008; 18(7):471-480. / PDF
- 23. Effler JC, Iglesias PA, Robinson DN.* A mechanosensory system controls cell shape during mitosis. Cell Cycle 2007; 6(1):30-35. / PDF
- 22. Kabacoff C, Xiong Y, Musib R, Reichl EM, Kim J, Iglesias PA, Robinson DN.* Dynacortin facilitates polarization of chemotaxing cells. BMC Biol. 2007; 5:53. / PDF
- 20. Effler JC, Iglesias PA, Robinson DN. Regulating cell shape during cytokinesis. In B.A. Francis and J.C. Willems, eds, Control of Uncertain Systems: Modelling, Approximation and Design, 2006; pp. 203-224. Springer-Verlag, New York. / PDF
- 18. Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN.* Mitosis-specific mechanosensing and contractile protein redistribution control cell shape. Curr. Biol. 2006; 16(19):1962-1967. / PDF