Pablo Iglesias
pi@jhu.edu
Academic Titles
Professor of Electrical Engineering
Publications
- 105. Kuhn JA, Banerjee P, Haye A, Robinson DN, Iglesias PA, Devreotes PN. Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity. bioRxiv; 2024. Feb. 13. DOI: https://doi.org/1101/2024.02.13.580131.
100. Plaza-Rodriguez A., Nguyen LTS, Robinson DN, Iglesias, PA. Particle-based model of mechanosensory contractility kit assembly. Biophys. J. 2022; 121: 1-15. DOI:https://doi.org/10.1016/j.bpj.2022.10.031 / PDF- 95. DiNapoli, KT, Robinson DN, Iglesias PA. A mesoscale mechanical model of cellular interactions. Biophys. J. 120: 4905-4917. doi: https://doi.org/10.1016/j.bpj.2021.10.021 / PDF
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93. Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial metabolism, surface hydration, and ciliary function. J. Cell Sci. 2021; 134(4): jcs257162. / PDF Featured in Scientific American - 90. DiNapoli K, Robinson DN, Iglesias PA. Tools for computational analysis of moving boundary problems in cellular mechanobiology. WIREs Mech. Dis. 2020; e1514 1-33. doi.org/10.1002/wsbm.1514 / PDF
- 88. Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial homeostasis, mitochondrial metabolism and ciliary function. bioRxiv DOI: 10.1101/2020.05.18.101378. / PDF
84. Kothari P, Johnson C, Sandone C, Iglesias PA, Robinson DN*. How the mechanobiome drives cell behavior, viewed through the lens of control theory. J. Cell Sci. 2019; 132:1-10. jcs234476. / PDF- 83. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14. Cancer Res. 2019; 79(18):4665-4678. / PDF
- 81. Schiffhauer ES, Ren Y, Iglesias V, Kothari P, Iglesias PA, Robinson DN*. Myosin IIB assembly-state determines myosin IIB mechanosensitive dynamics. J. Cell Biol. 2019; 218(3): 895-908. / PDF
- 75. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion. bioRxiv; DOI: 10.1101/190553. / PDF
- 65. Schiffhauer ES, Luo T, Mohan K, Srivastava V, Qian X, Griffis E, Iglesias PA, Robinson DN*. Mechanoaccumulative elements of the mammalian actin cytoskeleton. Curr. Biol. 2016; 26(11): 1473-1479. / PDF
- 62. Srivastava V, Iglesias PA, Robinson DN*. Cytokinesis: Robust cell shape regulation. Semin. Cell Dev. Biol. 2016; 53:39-44. / PDF
- 61. Mohan K, Luo T, Robinson DN, Iglesias PA. Cell shape regulation through mechanosensory feedback control. J. R. Soc. Interface. 2015; 12(109): 20150512. / PDF
52. Luo T, Mohan K, Iglesias PA, Robinson DN*. Molecular mechanisms of cellular mechanosensing. Nat. Mater. 2013; 12: 1064-1071. / PDF- 47. Robinson DN*, Iglesias PA*. Bringing the physical sciences into your cell biology research. Mol. Biol. Cell 2012; 23(21): 4167-4170. / PDF
- 42. Mohan K, Iglesias PA*, Robinson DN.* Separation anxiety: stress, tension, and cytokinesis. Exp. Cell Res. 2012; 318(12): 1428-1434. / PDF
- 41. Poirier CC, Ng WP, Robinson DN, Iglesias PA. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comp. Biol. 2012; 8(4): e1002467. / PDF
- 40. Kee YS, Ren Y, Dorfman D, Iijima M, Firtel RA, Iglesias PA, Robinson DN.* A mechanosensory system governs myosin II accumulation in dividing cells. Mol. Biol. Cell 2012; 23(8): 1510-1523. / PDF
- 39. Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN.* Understanding the cooperative interactions between myosin II and actin crosslinkers mediated by actin filaments during mechanosensation. Biophys. J. 2012; 102(2): 238-247. / PDF
- 33. Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Will ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN.* 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889. / PDF
- 30. Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA. Automated characterization of cell shape changes during amoeboid motility. BMC Systems Biology 2010; 4:33. / PDF
- 29. Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock, RS, Robinson DN.* Mechanosensing through cooperative interactions between myosin-II and the actin crosslinker cortexillin-I. Curr. Biol. 2009; 19(17):1421-1428. / PDF
- 27. Yang L, Effler JC, Kutscher BL, Sullivan SP, Robinson DN, Iglesias PA. Modeling cellular deformations using the level set formalism. BMC Systems Biology 2008; 2:68. / PDF
26. Reichl EM, Ren Y, Morphew MK, Delannoy M, Effler JC, Girard KD, Divi S, Iglesias PA, Kuo SC, Robinson DN.* Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics. Curr. Biol. 2008; 18(7):471-480. / PDF- 23. Effler JC, Iglesias PA, Robinson DN.* A mechanosensory system controls cell shape during mitosis. Cell Cycle 2007; 6(1):30-35. / PDF
- 22. Kabacoff C, Xiong Y, Musib R, Reichl EM, Kim J, Iglesias PA, Robinson DN.* Dynacortin facilitates polarization of chemotaxing cells. BMC Biol. 2007; 5:53. / PDF
- 20. Effler JC, Iglesias PA, Robinson DN. Regulating cell shape during cytokinesis. In B.A. Francis and J.C. Willems, eds, Control of Uncertain Systems: Modelling, Approximation and Design, 2006; pp. 203-224. Springer-Verlag, New York. / PDF
- 18. Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN.* Mitosis-specific mechanosensing and contractile protein redistribution control cell shape. Curr. Biol. 2006; 16(19):1962-1967. / PDF