To See the World in a Dividing Cell

If you are interested in supporting our research or our Summer Academic Research Experience (SARE) program for disadvantaged Baltimore youth, please contact Doug (dnr@jhmi.edu) or Geminesse Johnson, Associate Director of Development, Institute for Basic Biomedical Sciences (gjohns45@jhmi.edu).

See our newest press releases:

Proteins Pull Together As Cells Divide: Group dynamics, not star proteins, drive mechanics of crucial cell process

Like a surgeon separating conjoined twins, cells have to be careful to get everything just right when they divide in two. Otherwise, the resulting daughter cells could be hobbled, particularly if they end up with too many or two few chromosomes. Successful cell division hangs on the formation of a dip called a cleavage furrow, a process that has remained mysterious. Now, researchers at Johns Hopkins have found that no single molecular architect directs the cleavage furrow’s formation; rather, it is a robust structure made of a suite of team players. This work appeared online in Current Biology on February 19, 2015.  Please click here for the rest of the story.

 

Under Pressure: Mechanical stress is a key driver of cell-cell fusion, study finds

Just as human relationships are a two-way street, fusion between cells requires two active partners: one to send protrusions into its neighbor, and one to hold its ground and help complete the process.  Researchers have now found that one way the receiving cell plays its role is by having a key structural protein come running in response to pressure on the cell membrane, rather than waiting for chemical signals to tell it that it’s needed. The study, which helps open the curtain on a process relevant to muscle formation and regeneration, fertilization, and immune response, appears in the March 9 (2015) issue of the journal Developmental Cell.  Please click here for the rest of the story.

 

Stiffening Up Cancer Cells

A new screen uncovers compounds that alter cell mechanics. Could these compounds someday treat cancer from an unexpected angle? Find out by reading the story in Biotechniques.

 

New Cancer-Fighting Strategy Would Harden Cells to Prevent Metastasis

Existing cancer therapies are geared toward massacring tumor cells, but Johns Hopkins researchers propose a different strategy: subtly hardening cancer cells to prevent them from invading new areas of the body. They devised a way of screening compounds for the desired effect and have identified a compound that shows promise in fighting pancreatic cancer. Their study appeared January 20, 2015 in the early edition of the Proceedings of the National Academy of Sciences.  Please click here for the rest of the story.