Alexandra Surcel
Research Associate Faculty
alexandra.surcel@gmail.com
Appointments/Affiliations
AAAS Science and Technology Policy Fellowship
National Science Foundation Board Office
Academic Titles
PhD, Penn State Univ
Publications
- 91. Parajón E, Surcel A, Robinson DN*. The Mechanobiome: A Goldmine for Cancer Therapeutics. Am. J. Physiol.-Cell Physiol. 2021; 320: C306-C323. DOI: 10.1152/ajpcell.00409.2020 / PDF
- 89. Bryan DS, Stack M, Krystofiak K, Cichoń U, Thomas DG, Surcel A, Schiffhauer ES, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR. 4-hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis. Proc. Natl. Acad. Sci. USA. 2020; 117 (36) 22423-22429. doi.org/10.1073/pnas.2014639117 / PDF
- 83. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14. Cancer Res. 2019; 79(18):4665-4678. / PDF
- 82. Surcel A, Robinson DN.* Meddling with myosin’s mechanobiology in cancer. Proc. Natl. Acad. Sci. U.S.A. 2019; 116(31): 15322-15323. / PDF
- 75. Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN*. Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion. bioRxiv; DOI: 10.1101/190553. / PDF
- 73. Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. Entosis is induced by glucose starvation. Cell Rep. 2017; 20: 201-210. / PDF
- 66. Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, Liu Y, Wu N, Joseph NE, Wang T-L, Zhang N, Pan D, Alpini G, Robinson DN, Anders RA. Yes-Associated Protein impacts adherens junction assembly through regulating actin cytoskeleton organization. Am. J. Physiol. – Gastrointest. Liver Phys. 2016; 311(3): G396-G411. / PDF
- 57. Surcel A, Ng WP, West-Foyle H, Zhu Q, Ren Y, Avery L, Krenc AK, Meyers D, Rock RS, Anders RA, Freel Meyers C, Robinson DN*. Pharmacological activation of myosin II paralogs to correct cell mechanics defects. Proc. Natl. Acad. Sci. USA 2015; 112(5): 1428-1433. / PDF
- 55. Ren Y, West-Foyle H, Surcel A, Miller C, Robinson DN*. Genetic suppression of a phosphomimic myosin II identifies system-level factors promoting myosin II cleavage furrow accumulation. Mol. Biol. Cell. 2014; 25(25): 4150-4165. / PDF
- 46. Robinson DN*, Kee Y-S, Luo T, Surcel A. Understanding how dividing cells change shape. In Egelman EH (ed.) Comprehensive Biophysics, 2012; Elsevier, Amsterdam. Vol. 7, pp. 48-72. / PDF
- 34. Surcel A, Kee Y-S, Luo T, Robinson DN.* Cytokinesis through biochemical-mechanical feedback loops. Semin. Cell Dev. Biol. 2010; 21:866-873. / PDF
- 33. Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Will ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN.* 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889. / PDF